Cannabidiol has very low affinity for the cannabinoid CB1 and CB2 receptors but is said to act as an indirect antagonist of these receptors. At the same time, it may potentiate the effects of THC by increasing CB1 receptor density or through another CB1 receptor-related mechanism.
As more scientists recognize the compound’s potential, there has been an “explosion of research,” according to Pal Pacher, a pharmacologist and cardiologist at the National Institutes of Health in Bethesda. He has been studying the chemical for more than a decade; his work has shown that CBD may have benefits in both heart disease and diabetes.
Cannabis oil has a wide range of effects on health and has been connected to a diverse number of health problems, ranging from migraines and stress to lack of appetite and sex drive. Cannabis oil has even been connected to reducing the risk of certain cancers, as well as reducing pain, improving the conditions of the heart, and helping people get a good night’s sleep. There are a number of ways to use cannabis oil, depending on what you want relief from.
On July 3, 2014, North Carolina Governor Pat McCrory signed HB 1220 into law. The bill allowed universities to conduct clinical trials using CBD oil that was less than 0.3% THC and at least 10% CBD only for the treatment of intractable epilepsy.
Simply put, cannabinoids are naturally occurring compounds found in the cannabis plant. There are dozens of compounds including Cannabidiol (CBD), THC, and a host of other cannabinoids. Together they are responsible for the benefits and drawbacks to medical marijuana and industrial hemp-based products.
After clearing U.S. Customs inspection, we test the hemp oil again when it reaches our facilities. After a 10,000+ mile transcontinental trip, we follow proper safety protocol to double check for degradation, damage, or contamination in our oil.
According to the Georgia Department of Public Health, “The new law does not address how low THC oil is made, purchased or shipped. The law only creates a procedure to ensure qualified persons will be protected from prosecution for having it in their possession.”
Among common CBD benefits, natural pain relief tops the list for many. Evidence suggests that cannabinoids may prove useful in pain modulation by inhibiting neuronal transmission in pain pathways. A 2012 study published in the Journal of Experimental Medicine found that CBD significantly suppressed chronic inflammatory and neuropathic pain in rodents without causing analgesic tolerance. Researchers suggest that CBD and other nonpsychoactive components of marijuana may represent a novel class of therapeutic agents for the treatment of chronic pain. (4)
CBD oil is generally used for medicinal purposes, treating inflammation, pain, sleeping disorders and even certain types of epileptic seizures. Hemp-seed oil is used as a protein supplement for food, as varnish for wood and, because of its remedial properties for hair and skin, as an ingredient in the lotion and soap products you mentioned. You can buy hemp-seed oil online or at certain food stores, where you can learn about more ways to incorporate it into your diet and hygiene.
Jump up ^ Izzo AA, Borrelli F, Capasso R, Di Marzo V, Mechoulam R (October 2009). “Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb”. Trends in Pharmacological Sciences. 30 (10): 515–27. doi:10.1016/j.tips.2009.07.006. PMID 19729208.
Over the past decade and especially in recent years the medical field has invested a lot of time and resources into the study of CBD with some astounding results being discovered. Though it must be stated there is still much to uncover about the safety and efficacy of CBD products. But recent results from several studies from well respected medical institutions are suggesting CBD may help improve the quality of life for many people through providing a safe, powerful and natural treatment for many different health conditions.
“CBD is kind of a tricky drug because it’s not very well absorbed orally,” Welty explained. “Less than 20 percent of the drug is absorbed orally. If it isn’t made in the right way, you may not be getting much drug into your systemic circulation.”
Hemp – Hemp refers to the high-growing varieties of cannabis that are grown to be specifically used for fiber, oil, and seeds. These are then refined into numerous products including wax, resin, cloth, pulp, paper, rope, fuel, and hemp oil.
The Food and Drug Administration on 6/25/2018 approved the first drug derived from marijuana, which will be used to treat two rare and severe forms of childhood epilepsy. FDA Commissioner Scott Gottlieb said the approval was “a reminder that advancing sound development programs that properly evaluate active ingredients contained in marijuana can lead to important medical therapies.” He noted that the action was “not an approval of marijuana or all of its components” but rather of one specific CBD medication for a particular use. In April, an advisory committee unanimously recommended approval of the drug for the two types of epilepsy.
Actually, no. BUT – there’s a very good reason for that! Because Functional Remedies’ CBD Oil, CBD Hemp Tincture and other sustainable hemp products are classified as dietary supplements by the FDA, we can’t make any specific claims as to what diseases and conditions they treat. So, while we are unable to speak to specific diseases and conditions, there are large (and growing) array of sites, online resources, and scientific research from around the world that point to the many beneficial uses of hemp oil & CBD. We also encourage you to sign up for our email list and we’ll send you lots of valuable information about CBD as well as updates and news that are cutting edge.
If you’re just diving into the world of CBD, we recommend a starting serving size of two to three milligrams. From there, you can work your way up to 100 or even 200 milligrams, after you’ve taken the time to gradually observe how CBD affects your body and mind. Remember, you cannot overdose on CBD, and there are no reported side effects from taking high concentrations. Always refer to the dosage guidelines on the product packaging if you are unsure.
Cannabis ruderalis is a species native to Russia that flowers earlier and is able to withstand harsher conditions than Cannabis sativa and Cannabis indica. It is the hardiest of the three, but it is relatively poor in terms of cannabinoids as ruderalis has a lower THC content than either sativa or indica.
Clara is a cannabis enthusiast evolving in the city of Barcelona, a vibrant hub for the European cannabis industry. She believes in free access to cannabinoids, and joined Harmony to spread word of CBD to the world.
Wade, D. T., Robson, P., House, H., Makela, P., and Aram, J. A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Clin.Rehabil. 2003;17(1):21-29. View abstract.
Another study published in Current Pharmaceutical Design found that CBD may have similar effects to certain antipsychotic drugs and that it may be safe and effective in treating patients with schizophrenia.
“There’s no control, so it’s basically how do you know if we’re dealing with the true effect of the drug or just simply a placebo effect because somebody thinks they’ve been given a drug that will be beneficial?” Welty said.
THC is the cannabis plant’s psychoactive ingredient but there are more than 100 other chemical compounds in the plant, so CBD doesn’t actually get you high. It’s extracted by soaking the plant in alcohol and then evaporating the liquid.
Some test-tube and animal studies have even shown that CBD may have anticancer properties. For example, one test-tube study found that concentrated CBD induced cell death in human breast cancer cells (19).
Benefits of castor oil for the face and skin A look at the benefits of castor oil for the face and skin. Included is detail on how to use castor oil and the potential side effects of which to be aware Read now
I would like to thank you so much for your products, specifically Natural CBD Oil. In just two applications my wife’s severe psoriasis is nearly gone and no more itching. Also her headaches from shingles is all gone and she has been having those headaches for almost three years. She also has NO problem any more with not being able to sleep. My German Shepherd has had problems with his skin itching and he has licked his legs raw. All this has almost entirely disappeared. And I have had severe pain in my neck from a car accident many years ago. When I put this on my neck the pain has been minimalized. Not gone but very bearble. All I have left to say is THANK YOU THANK YOU THANK YOU. And THANK YOU from my wife and my dog. Most assuredly, I will be purchasing more of your lifsaving product. Again Thank You!!!!!!!!!!
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If there is a clear downside to CBD it’s the taste. Holland & Barrett suggests dropping it under the tongue two or three times per day, but warn that the thick oil has a “distinctive” flavour. It’s been described as a strong, earthy taste – and a glass of water alongside is recommended.
From the sound of it, you might think leaky gut only affects the digestive system, but in reality it can affect more. Because Leaky Gut is so common, and such an enigma, I’m offering a free webinar on all things leaky gut. Click here to learn more about the webinar.
Massi, P., Vaccani, A., Ceruti, S., Colombo, A., Abbracchio, M. P., and Parolaro, D. Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharmacol Exp.Ther. 2004;308(3):838-845. View abstract.
The NIH recognizes the need for additional research on the therapeutic effects of CBD and other cannabinoids, and supports ongoing efforts to reduce barriers to research in this area. NIH is currently supporting a number of studies on the therapeutic effects as well as the health risks of cannabinoids. These include studies of the therapeutic value of CBD for:
One key area of CBD research is epilepsy. Several scientists are focusing on its potential to reduce seizures, especially among those for whom other treatments have failed. “We’ve found significant positive effects with CBD,” says New York University neurologist Orrin Devinsky, who studies the compound for severe childhood epilepsy.
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You may have heard some people say that marijuana and hemp are exactly the same, while others swear they are different. The debate of hemp vs marijuana is fueled by the confusion and misinformation that surround the cannabis plant.
As we have also seen above, CBD is considered to have wider applications than THC. Since CBD has been much less studied than THC, scientists assume that there are many new applications of CBD that haven’t yet been discovered. On the other hand, THC’s applications are more or less completely explored by now due to all the research on medical marijuana over the past decade.
She said that clinical trials showed that CBD (Epidiolex) can be very effective in the treatment of refractory epilepsy in Dravet syndrome and Lennox Gastaut syndrome and that there is promising evidence to suggest it could help other types too.
A budtender at Natural Remedies in Denver turned me on to Concentrate Remedies’ Live Resin Cartridge, and it’s the closest experience I’ve had to live resin in cartridge form. Each cartridge is filled with strain-specific live resin that’s butane-extracted by Concentrate Remedies from fresh frozen material grown by Natural Remedies. Each cartridge has a ceramic heating element that maintains a consistent and uniform flavor.
A research paper on the NCBI website concluded some potential side effects for CBD. One such side effect is the inhibition of hepatic drug metabolism, and the decreased activity of glycoprotein. Cannabinoids can influence some pharmaceutical drugs through the process of inhibiting liver enzymes called cytochrome p450. It’s important to consult with your doctor because this effect is not always considered an adverse side effect.
On July 1, 2015, HB 32became law after Gov. Matt Mead neither signed the bill nor vetoed it, allowing the use of hemp extract that contains at least 15% CBD and no more than 0.3% THC for the treatment of intractable epilepsy.
Cannabis vape pens have come a long way since their earliest iterations. What began as a small selection of pens with questionable hardware and ingredients, high-quality oil cartridges have since become one of the most popular products available at cannabis dispensaries. Nowadays, there are now so many quality cartridges to choose from, the hardest part is making a selection.
The finished products are then tested for a final time to once again ensure the safety, quality, and cannabinoid content of our products. This is our standard Triple Lab Testing™ process that all our CBD oil products complete.
Iffland K, Grotenhermen F (2017). “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies”. Cannabis Cannabinoid Res. 2 (1): 139–154. doi:10.1089/can.2016.0034. PMID 28861514.
Unlike medical cannabis abundant in the psychoactive ingredient Δ9-THC, modern hemp has been selectively bred to produce low levels of Δ9-THC and high levels of fiber, seed, and, more recently, cannabidiol (CBD). Most of the European Union and Canada have recognized the value of hemp and have defined a legal limit of 0.3% Δ9-THC in the dry plant material (Small and Marcus, 2003), with the exception of Italy (0.2% Δ9-THC) (Cappelletto et al., 2001). Many hemp cultivars are rich in cellulose used for biofuel, primary fibers for pulping, fine fiber textiles, dense flowering varieties that offer abundant seed, or high CBD-to-Δ9-THC ratios. Hemp varieties resistant to drought, high soil salinity, cold, heat, humidity, and common pests and diseases have been selected to improve yields (Watson and Clarke, 2014). To date, 51 hemp cultivars have been approved for commercial use by the European Union (Directive, 2013). These registered varieties originate from high-latitude European nations, which are not acclimated for equatorial regions of the world. Little is known about the viability of the European cultivars in the United States, and it is currently being examined by agronomists.
I just started my little 17-year-old Chihuahua on products from Canna-Pet last evening. (I gave him one “Advanced” capsule) This morning I started him on “Advanced MaxCBD Liquid” He has extreme difficulty walking and most of the time can not even stand up anymore. Late this afternoon when I carried him outside to do his business, I noticed he had more strength in his right leg. I can’t really give a full review here due to it being too soon, however, if you go to the Canna-Pet web site, you will see many positive reviews; I spent hours on their site. I bought one bottle of liquid, one bottle of capsules and one box of biscuits because their products have given me hope, where so many other products have failed. Good luck Cynthia!!
^ Jump up to: a b Scuderi C, Filippis DD, Iuvone T, Blasio A, Steardo A, Esposito G (May 2009). “Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders”. Phytotherapy Research (Review). 23 (5): 597–602. doi:10.1002/ptr.2625. PMID 18844286.
Hemp seed oil is an extract from the seeds of industrial hemp. Industrial hemp is the only plant used in crafting this type of hemp oil. Hemp seeds are cold pressed, peeled or unpeeled, to create a delicious nutty oil.
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