Toth CC, Jedrzejewski NM, Ellis CL, Frey WH. Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type 1 diabetic peripheral neuropathic pain. Mol Pain 2010;6:16. View abstract.
THC (Tetrahydrocannabinol) Cannabis oil and Cannabidiol (also called CBD) have similarities but some important differences for users. Both cannabinoids, chemical compounds that can be found in all cannabis plants, including hemp and marijuana. Cannabinoids are the substances secreted by the flowers of the cannabis plant and contain natural medicinal properties, offering relief from conditions including anxiety, pain, nausea, and inflammation. There are plant-based cannabinoids and also phytocannabinoids, both with a variety of health benefits.
Massi P, Valenti M, Vaccani A, et al. 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem 2008;104(4):1091-100. View abstract.
Xong, W., Cui, T., Cheng, K., Yang, F., Chen, S. R., … & Zhang, L. (2012, June). Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. Journal of Experimental Medicine, 209(6), 1,121-1,134. Retrieved from www.ncbi.nlm.nih.gov/pmc/articles/PMC3371734/
I was reading Tina’s review casually when I SAW MYSELF! Low to little or at times no energy. Constant pain in joints, knee pain – bone to bone. Shoulders busted – torn rotators. Head, neck & shoulder injuries – all from military & LE as Motorcycle Officer. DAV & Disabled cop, went down in ‘98.
Valenti M, Massi P, Bolognini D, et al. Cannabidiol, a non-psychoactive cannabinoid compound inhibits human glioma cell migration and invasiveness. 34th National Congress of the Italian Society of Pharmacology 2009.
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Longer answer: Hemp and marijuana are both cannabis, and both work with the endocannabinoid system in the body, but there are a few key differences. Marijuana has a high concentration of THC – the cannabinoid that makes you feel “high”. Hemp has a very low concentration of THC (less than 0.3%), does not get you high, and is legal in all 50 states without a medical marijuana card. Hemp has a much higher concentration of CBD than marijuana, as well as numerous of other cannabinoids that work with your endocannabinoid system to bring about greater overall health and vitality.
We are all aware of the promising therapeutic benefits that can be derived from using CBD oil, but it also may interact poorly with other prescription and over-the-counter drug and medications. Since side effects are unavoidable when taking CBD extracted from both hemp and marijuana, its interaction with drugs that are taken simultaneously may result in adverse effects or serious complications. Hemp CBD oil can inhibit the liver’s ability in processing certain medications, which may result in an overall increase in processing times. As the liver experiences difficulty in metabolizing, drugs stay longer in the body. In some cases, the interaction could cause serious side effects or even overdose. With this in mind, you should consult your physician before starting on any hemp CBD oil therapy and may be required to alter your CBD dosage.
Consroe, P., Kennedy, K., and Schram, K. Assay of plasma cannabidiol by capillary gas chromatography/ion trap mass spectroscopy following high-dose repeated daily oral administration in humans. Pharmacol Biochem.Behav. 1991;40(3):517-522. View abstract.
It can feel impossible to know which CBD brands are reputable and which are not. The goal of our independent CBD brand and product reviews is to help you feel empowered to make that decision. We only retail five-star verified brands, so you can
Our understanding of CBD cannabis oil has expanded and we’re more aware today than ever of the cannabinoid’s potential. Studies on CBD’s natural health benefits are extensive and groundbreaking research is being done regularly. We suggest you review the wide body of scientific research on CBD to get a better understanding of the cannabinoid’s health value. We answer the “Will CBD get you high?” question here.
At Harmony, we are always happy to answer any questions and ensure that our valued clientele can purchase products that are right for their individual needs. Contact us if you wish to receive our certificate of analysis!
Can CBD oil relieve arthritis pain? Recent studies suggest that canabidiol oil (CBD oil) could play a role in treating arthritis. What are the benefits CBD oil and are there any side effects? Read now
Jump up ^ Iffland K, Grotenhermen F (2017). “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies”. Cannabis Cannabinoid Res. 2 (1): 139–154. doi:10.1089/can.2016.0034. PMC 5569602 . PMID 28861514.
Let’s start by looking at THC. THC (tetrahydrocannabinol) is the compound found in cannabis with psychotropic properties. Medical marijuana companies breed their plants to have the highest concentrations of this compound. It is associated with the feeling of being high that marijuana smokers experience. Effects include feelings of euphoria, pain relief and sometimes increased anxiety and paranoia.
Hemp-producing cannabis has tall, fibrous stalks that are very strong and have very few flowering buds. On the on the other hand, marijuana strains are short, bushy, and have high amounts of THC. In fact, industrial hemp and medical marijuana are so distinctively different that most lay people wouldn’t be able to tell that they belong to the same genus of plants if they encountered them in the wild!
You may have heard some people say that marijuana and hemp are exactly the same, while others swear they are different. The debate of hemp vs marijuana is fueled by the confusion and misinformation that surround the cannabis plant.
It depends on what kind of hemp oil it is. It needs to be therapeudic grade, not hemp culinary oil. CBD is in my experience and opinion far superior to any other. It is non psychotropic but has all of the healing properties.
In the cannabis plant, CBD and THC generally have an inverse relationship: The more THC there is, the less CBD, and vice versa. In recent years, growers have bred some plants to contain high levels of CBD. Some say the two compounds work synergistically and that for many ailments, combining CBD and THC is best.
Faced with the huge demand for safe and natural treatment options due to the rapidly aging U.S. population, people are doing their homework about products such as CBD. But they’re also learning that CBD is a far better alternative, as taking THC or Cannabis oil can come with some serious side effects…and possibly even legal problems!
THC – The most abundant constituent of the cannabis plant and a strongly psychoactive cannabinoid, THC is responsible for getting “high” from smoking marijuana and, as a result, its production and usage are strictly regulated.
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For example, one study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic nerve pain and inflammation (5, 6).
Blue Label Oil is one of the strongest and most concentrated CBD products on the market. With a recommended serving the size of a grain of rice taken orally twice a day, its potent punch acts quickly—in just ten to fifteen minutes—to provide powerful relief.
Mr. Chairman, Ms. Chairwoman, and Members of the Senate Drug Caucus, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), to participate in this hearing to share what we know about the biology and the potential therapeutic effects of cannabidiol (CBD), one of the main active chemical compounds found in marijuana. In light of the rapidly evolving interest in the potential use of marijuana and its derivative compounds for medical purposes, it is important to take stock of what we know and do not know about the therapeutic potential of CBD.
Jump up ^ Stockings E, Zagic D, Campbell G, Weier M, Hall WD, Nielsen S, Herkes GK, Farrell M, Degenhardt L (July 2018). “Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence”. J. Neurol. Neurosurg. Psychiatry. 89 (7): 741–753. doi:10.1136/jnnp-2017-317168. PMID 29511052.
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Acne affects almost 1 in 10 people throughout the world. Although acne is caused by many different factors such as genetics, bacteria, inflammation and the overproduction of sebum. Thanks to recent studies it appears CBD may help with Acne due to its inflammatory qualities and its ability to lessen the production of sebum. Two separate studies found that Cannabidiol stopped sebaceous gland cells from producing excess sebum, utilizing CBD’s anti-inflammatory properties to prevent the activation of pro-acne agents such as inflammatory cytokines.
Lehmann, C., Fisher, N. B., Tugwell, B., Szczesniak, A., Kelley, M., & Zhou, J. (2016). Experimental cannabidiol treatment reduces early pancreatic inflammation in type 1 diabetes [Abstract]. Clinical Hemorheology and Microcirculation, 64(4), 655-662. Retrieved from www.ncbi.nlm.nih.gov/pubmed/27767974
Since THC and Cannabis oils contain a higher percentage of THC, it still causes users euphoric and psychoactive reactions, similar to the feelings when people take marijuana recreationally. Besides the high that you experience, THC oil delivers a long list of short-term effects, which are similarly present when you smoke or ingest marijuana. Each person’s reaction may vary in the symptoms it causes and their degree.
Another study published in Current Pharmaceutical Design found that CBD may have similar effects to certain antipsychotic drugs and that it may be safe and effective in treating patients with schizophrenia.
In addition, some cannabinoids interact synergistically, producing unique effects that are not found when using them individually. For example, CBD inhibits THC’s psychotropic effects when the two are taken together. However, CBD does this (and produces many other effects) without directly interacting with the cannabinoid receptors. At first, scientists thought there was a third type of CB receptor just for Cannabidiol, but the answer was far more interesting and revealing.
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For Lisa Leyden, Jackson’s mother, these issues don’t negate the compound’s enormous potential. “I realize this isn’t perfect,” she says. “We absolutely need to know more. But in the meantime, many people need help. They’re in bad shape, and this seems to work.”
Derived from the stalk and seed of cannabis (hemp) plants, cannabidiol (CBD) oil or CBD hemp oil is a natural botanical concentrate that is high in the compound CBD. Of the more than 85 cannabinoids so far identified in the cannabis plant, CBD is the second most common after tetrahydrocannabinol (THC). Unlike THC, CBD is non-psychotropic and therefore doesn’t cause a euphoric high.
A 2013 study published in the British Journal of Clinical Pharmacology reports that CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models; plus, CBD proved to reduce the vascular hyperpermeability (which causes leaky gut) associated with such environments. (18)
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